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Compatible with most 510-thread batteries
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DMT Administration Routes & Doses
DMT was administered via intranasal (IN) or subcutaneous (SC) routes
Doses tested: 1, 3, and 10 mg/kg (DMT fumarate salt)
IN injections required brief isoflurane anesthesia (15–30 seconds)
SC injections required no anesthesia
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Pharmacokinetic Findings (Buy Deadhead Chemist 5-MeO-DMT Cartridge)
| Parameter | IN DMT | SC DMT |
|---|---|---|
| Half-life (t½) | 11.9 – 14.3 minutes | 45.5 – 122.7 minutes |
| Cmax | Higher than SC | Lower than IN |
| tmax (time to peak) | Consistent across doses | Delayed at higher doses |
| AUC at 10 mg/kg | 5,626 min*ng/mL (non-linear accumulation) | Dose-proportional |
| Clearance | Faster than SC | Slower than IN |
Behavioural Findings (Observed in Rats)
Flat body posture (5-HT1A-mediated):
IN DMT: increased at 3 and 10 mg/kg
SC DMT: increased only at 10 mg/kg
Wet dog shakes (5-HT2A-mediated):
SC DMT: significant increase at 1 and 3 mg/kg
IN DMT: no statistically significant increase
Motor activity:
No significant differences across doses for either route
Body Temperature Findings (Measured in Rats)
IN DMT, all doses caused reduced body temperature by 20 minutes post-treatment. At 10 mg/kg, the temperature dropped to 34.4°C and stayed low for 80 minutes.
SC DMT: Only 10 mg/kg caused reduced body temperature. The temperature dropped to 34.2°C but returned to normal by 160 minutes.
Saline controls (IN or SC): No hypothermia observed.
DMT N-Oxide Findings | Buy Deadhead Chemist 5-MeO-DMT Cartridge
DMT N-oxide concentrations in rat plasma tracked closely with parent DMT concentrations
DMT N-oxide reached similar absolute concentrations to DMT in rats
The study authors note this differs from humans, where DMT N-oxide is much lower
Correlation Findings (Statistical)
DMT concentrations positively correlated with flat body posture scores for both IN and SC routes
DMT concentrations positively correlated with DMT N-oxide concentrations for the IN route only
DMT concentrations were negatively correlated with body temperature for the SC route only
DMT concentrations showed no significant correlation with body temperature for the IN route
Direct Quotes from the Source (Verbatim)
“IN administration engendered more rapid kinetics when compared to SC administration.”
“The t½ values for IN DMT ranged from 11.9 to 14.3 minutes.”
“There is great interest in investigating and developing alternative, non-invasive drug delivery routes for therapeutic dosing of DMT without MAOIs.”
“A key limitation of the present analytical method is the absence of the DMT metabolite, indole-3-acetic acid (IAA).”
“Our findings provide proof-of-principle evidence that DMT can be safely and effectively administered by the IN route in rats.”
Limitations Stated by the Authors
IAA (main DMT metabolite) was not quantified due to poor recovery
Small sample size: n=5 rats per dose group
Isoflurane anesthesia for IN dosing may have affected both behavioural and temperature results.
Species difference exists between rats and humans in DMT metabolism (rats produce more DMT N-oxide)
Where to buy DMT in the UK
You can buy it at necrodispensary.com
| Weight | 25g, 50g, 100g, 500g, 1kg |
|---|






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